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M94A2804.TXT
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1994-10-25
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Document 2804
DOCN M94A2804
TI Inhibition of the antibody response to an HIV vaccine by maternal
antibody.
DT 9412
AU Jelonek M; Maskrey J; Steimer K; Potts B; Higgins K; Keller M;
Harbor-UCLA Medical Center, Torrance.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):220 (abstract no. PB0308). Unique
Identifier : AIDSLINE ICA10/94369771
AB We developed the murine model to assess the effects of passively
transferred polyclonal maternal anti-rgp120 antibodies on the subsequent
immunization of the offspring with rgp120SF2-CFA. Adult female BALB/c
mice were immunized with native, glycosylated rgp120SF2 in complete
Freund's adjuvant six weeks prior to mating. The offspring were then
immunized with 100 micrograms rgp120SF2-CFA at three weeks of age. The
anti-rgp120 IgG response was markedly suppressed for offspring of
immunized mother mice compared to control offspring [Titer of 1543 vs.
10,045, p < 0.0001]. Maternal immunization also profoundly inhibited the
V3 antibody response of offspring as assessed by ELISA antibody to the
V3 loop peptide, RP150. There was no inhibition of the response to an
unrelated protein, hen egg-white lysozyme, by maternal anti-rgp120SF2
antibody indicating that the inhibition of the response was antigen
specific. Since newborns at risk for HIV will be immunized in the
presence of either maternal or administered antibody (HIVIG, mAb or
polyclonal Ab), alternative strategies may be required to circumvent the
inhibition of the response to vaccination by pre-existing antibodies.
DE Animal Animals, Newborn/IMMUNOLOGY AIDS Vaccines/*IMMUNOLOGY Female
HIV Antibodies/*BIOSYNTHESIS/IMMUNOLOGY HIV Envelope Protein
gp120/*IMMUNOLOGY HIV-1/*IMMUNOLOGY *Immunity, Maternally-Acquired
Immunization Mice Mice, Inbred BALB C Peptide Fragments/IMMUNOLOGY
Pregnancy Recombinant Proteins/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).